Aging:
Skin aging is a dermatologic change that progresses as a person ages or is exposed to ultraviolet radiation (UVR) if no treatment is adopted. The extensive research activities are focused on this skin concern that involves the appearance of unpleasant, observable marks on the skin surface due to proteolysis of cutaneous elastic fibers resulting in reduced cell functions. Skin aging can be divided into two types, that is, intrinsic aging or chronological aging (inevitable phenomenon) and extrinsic or premature or photoaging (evitable phenomenon) owing to physiological and environmental factors, respectively. Morphologically, photoaging is characterized by dry, rough, pigmented, and abraded skin, especially on the face and hands in individuals who live in sunny geographical regions and are chronically exposed to direct sunlight. Conversely, fine, smooth wrinkles on dry, pale skin impart the characteristics of intrinsic aging. Diagnostically, intrinsic skin aging is identified by seborrheic keratosis which is not a biomarker of photoaging. Pathologically, the photodamaged skin shows vascular damage that is absent in intrinsically aged skin. An increased skin vascularization and angiogenesis are observed in the photoaged skin. Microscopically, a thicker epidermis is another feature of the photoaged skin.

It is noteworthy that the strength and resiliency of skin depend on the proper and uniform arrangement of collagen (types I and III) fibrils and elastin in the dermis; thus, collagen deficiency may result in skin aging due to the production of collagenase and thymine dimer in the skin on exposure to UVR. Histologically, the extracellular matrix of intrinsically aged skin possesses diminished levels of elastin, while the elastin amassing in the photoaged skin is observed just below the dermal-epidermal junction. Elastin is a fibrous protein that is reduced in thickness from deeper to superficial dermis. It provides natural elasticity and strength to the human body. It also plays a role in tissue repair. The basic and the major molecular unit involved in the construction of human skin is collagen which is produced from procollagen.

Collagen is a protein that is present in the connective tissues of the human body. The dermal fibroblasts generate the procollagen under the effect of transforming growth factor-𝛽 (TGF 𝛽) and activator protein-1 (AP-1), where TGF-𝛽 and-1 govern the production and breakdown of collagen, respectively. Under the effect of UVR received from the sun, the upregulation of matrix metalloproteinases (MMPs) enzymes secreted by keratinocytes, fibroblasts, and other cells promotes breakdown of collagen by AP-1 as well as a decrease in collagen synthesis. It results in the breakdown of the connective tissues during photoaging. During adulthood, there is about a 1%decrease in collagen content per year, but this rate is higher in aged people since old age people have higher levels of MMP[1].

So aging is a biological process that the most appearance of it shows on our face and we never can stop it. Even the best skin care products can not fight the aging process and what happens to our cells. Fine lines appear on our faces and they get deeper and deeper over time. We can’t stop it but we can reduce its obviousness. Some kinds of skin care products like serums, creams and masks can be effective to fade these lines. The only thing you need to know is to choose the proper products for your skin. Don’t forget that:
1- Some skin products contain a lot of chemical materials that hurt your skin or make problems for your nerves and blood. Try to find products like serums, creams and masks with herbal ingredients. Probably it takes more time to see their results but you can get sure that they don’t have any side effects.
2- Some skin care products change your look so fast and deep. But they don’t last for a long time and you always have to pay again and again for them. If you can find a proper product like serums, creams and masks you can expect long-lasting results.
3- You need to find a multi-functional product that can protect your skin against all damages, not just aging. Some skin care products contain a variety of Vitamins, Antioxidants, and other materials your skin needs. In this way, you can save more time and money.
4- And most of all, don’t forget that it’s not enough to just use skin care products. Try to have a more balanced lifestyle. Watch your feeding and sleep; Exercise more and avoid stress; Drink a lot of water; Don’t smoke and remember that alcohol is not good for your skin.

[1] Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity
Saima Jadoon1, Sabiha Karim2, Muhammad Hassham Hassan Bin Asad3, Muhammad Rouf Akram4, Abida Kalsoom Khan5, Arif Malik6, Chunye Chen7, and GhulamMurtaza3
1Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq
2University College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan
3Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
4Department of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan
5Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
6Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore 54000, Pakistan
7Key Laboratory of Biorheological Science and Technology, Chongqing University, Chongqing 400030, China
Correspondence should be addressed to Ghulam Murtaza; [email protected]
Received 12 December 2014; Accepted 13 March 2015
Academic Editor: Gabriele Saretzki
Copyright © 2015 Saima Jadoon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.